Having used KeePass for years I’ve longed for a way to secure the window while still auto-typing with shortcuts or integration plug-ins. So recently I made LockyWindow as a paid plug-in for the professional edition (v2) of KeePass password safe.
Unlocking the window can be done with the master password or a customizable quick-unlock PIN. The locking period can be customized to fit your preference. One can also lock or unlock using the shortcut or menu item.
You can find out more on the product page at PaulRRogers.com/lockywindow.